Molecular Therapeutics®
“Innovations In Microbial Control”
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Acute Gasoline Burn Wound - Clinical Case
Post Care
A 57 year old firefighter with partial thickness thermal burns to the face. Patient was treated with a polyurethane foam dressing saturated with Silvion. Within 3 hours of application of Silvion saturated dressings, the patient reported an 80% reduction in pain. All dressings were discontinued on day 10 and the face was sprayed with Silvion four times per day for an additional three days.
Chronic (5 months) Pressure Ulcer, Stage IV - Clinical Case
Day of presentation
Post Care
A 74 year old male with non healing stage IV sacral decubitus ulcer with osteomyelitis. Patient was admitted to the hospital for esophageal cancer surgery. Multisystemic organ failure occurred post surgery. During his hospital stay, he developed a sacral ulcer which required four surgical debridements as well as active wound management including VAC therapy. Despite extensive therapy, the Stage IV pressure ulcer located on the sacrum had been present for approximately 5 months at the time of presentation to the wound care center. It has decreased in size from its original measurement of 6 cm x 9.2 cm x 4 cm. Patient healed with use of Silvaklenz and Silvion, off loading, adequate nutrition and HBOT. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Day 12 of SilvaKlenz and Silvion use. MRSA Negative
Several days after Post-Surgical Debridement
Wound Infected with MRSA
Minimal Second Intention Healing on Other Therapy
Approximately 1 month of Other Therapy
Wound Remained Infected with MRSA
72 year old, male Dehisced Tibial - Vein Graft Site Infected with Nosocomial MRSA. Physician Recommends BID cleansing with SilvaKlenz and packing with Silvion soaked gauze 4x4s
Day 28
Dehisced Wound Infected with Nosocomial MRSA - Clinical Case
Final stage of Care
Day of Presentation
Post Care
Chronic (5 months) Stage IV Ulcer - Clinical Case
68-year-old male presented with a chronic (5 months) non healing Stage 4 sacral ulcer with osteomyelitis. Patient had back surgery followed by a fall and fracture of the left hip requiring surgical repair. He was subsequently diagnosed with DVTs, was found unresponsive, emergency transported to CCU where he was ventilated and subsequently contracted pneumonia/sepsis. He was then transferred to a rehab facility where he developed a sacral ulcer.
The chronic unresponsive Stage IV pressure ulcer located on the sacrum is thought to be related to osteomyelitis. The ulcer decreased in size from its original measurement of 3.5 cm x 3.5 cm x 2.8 cm. Patient managed with HBOT, Silvaklenz and Silvion, off loading, adequate nutrition and control of BS. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Final stage of Care
Day of Presentation
66-year-old male presented for a chronic non healing diabetic ulcer. The Wagner Grade 1 ulcer located on the right posterior foot/heel had been present for approximately 8 months at the time of presentation. The ulcer is thought to be related to Diabetes. Ulcer decreased in size from its original measurement of 2.5 cm x 0.6 cm x 1 cm. Patient managed with off loading, Silvaklenz and Silvion, control of BS and nutritional management.
Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Chronic (8 months) Non-Healing Diabetic Ulcer - Clinical Case
Post Care
1 Month Post Presentation
Day of Presentation
Chronic (4 month) Non-Healing Ulcer - Clinical Case
43-year-old male presented for chronic non healing ulcer. Patient had been managed by a wound specialist that used multiple debridements and systemic antibiotics without resolution. The ulcer decreased in size from its original measurement of 2.6 cm x 2.4 cm x 1.7 cm. Patient managed with Silvaklenz and Silvion, off loading and adequate nutrition. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
89 year old, Bedridden female with Chronic Diabetes Foot Ulcer Infected since 6-25-10 Minimal change after a month on Other Therapy. Physician Initiated use of SilvaKlenz and Silvion on 7-26-2010
16 Days using
SilvaKlenz and Silvion
Infected Foot Ulcer - Clinical Case
Fully Resolved at 65 Days using SilvaKlenz and Sivion
30 Days on Other Therapy
31 Days using SilvaKlenz and Silvion
Day of Presentation
Post Care
Chronic (1 month) Soft Tissue Radiation Necrosis - Clinical Case
69-year-old male presented for soft tissue radiation damage two weeks after completion of radiation therapy for SCCA of base of tongue. The chronic unresponsive radiation necrosis located on the neck was present for approximately 1 month. Patient managed and responded to care with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
4 Months of Other Therapy
1 Month of SilvaKlenz & Silvion Use
69-year-old female developed a post surgical wound and abscess (with purulent drainage) after placement of a pacemaker. The abscess was drained and the pacemaker was removed. At the time of presentation to the wound care center, the area had not healed despite appropriate antibiotics per ID and wound care per home health. Wound decreased in size from its original measurement of 4 cm x 1.1 cm x 0.8 cm. Patient managed with Silvaklenz and Silvion, adequate nutrition and home health to change the dressings. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Chronic (4 months) Post Surgical Wound - Clinical Case
Chronic, Unresponsive Gasoline Burn Wound - Clinical Case
Day of Presentation
Day 3
Day 11
A 24 old male with deep and superficial partial thickness gasoline burns. Initial treatment with Silvadene cream and Aquacel Ag wound dressings resulted in formation of escar, patient discomfort and reduced range of motion (shown in photos on day of presentation). Skin grafting surgery was suggested. Patient received alternative treatment using silver impregnated bandages saturated with Silvion. Patient reported significant pain reduction and improved range of motion within 2 hours of treatment, and pain medication was no longer necessary. Bandages were remoistened with Silvion every 12 hours, and changed on day 3 and 6.
Day of Presentation
Post Care
Chronic (3 months) Diabetic Ulcer - Clinical Case
82-year-old female presented for chronic (3 months) non healing diabetic ulcer. Patient sustained a hip fracture and developed a Wagner Grade 1 ulcer on the left heel during post-surgical rehab. The ulcer is thought to be related to Diabetes. The ulcer decreased in size from its original measurement of 0.5 cm x 0.7 cm x 0.3 cm. Patient managed with Silvaklenz and Silvion, off loading, control of BS and adequate nutrition.
Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
2nd Degree Burn - Clinical Case
56 year old, female with Chronic Diabetes and Hypertension Physician Initiated SilvaKlenz and Silvion 9-30-10
Day 1
Day 4
Day 16
Post Care
Day of Presentation
Post Care
Chronic (3 months) Non-Healing Pressure Ulcer - Clinical Case
91-year-old male presented for chronic (3 months) non healing ulcers on the left heel. The ulcer decreased in size from its original measurement of 3.2 cm x 2.7 cm x 0.3 cm. Patient managed with Silvaklenz and Silvion, off loading, control of BS and adequate nutrition. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Day of Presentation
Post Care
Non-Healing (1.5 month) Post Surgical Leg Wound - Clinical Case
80-year-old male presented for chronic (1.5 month) non healing post surgical wound resulting from a lipoma removal. The wound decreased in size from its original measurement of 1.8 cm x 1.5 cm x 1 cm. Patient managed with Silvaklenz and Silvion, compression and adequate nutrition. Patient managed with Silvaklenz and Silvion, compression and adequate nutrition. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Ongoing Care
Day of Presentation
69-year-old female presented for chronic (6 months) non healing arterial ulcer on the left medial ankle, thought to be related to atherosclerosis. The ulcer decreased in size from its original measurement of 2.7 cm x 1.5 cm x 0.7 cm. Patient managed with HBOT, Silvaklenz and Silvion and debridement. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Chronic (6 months) Non-Healing Arterial Ulcer - Clinical Case
Day of Presentation
Post Care
Chronic Non-Healing Pressure Ulcer, Stage III - Clinical Case
84-year-old male presented for non healing Stage III sacral pressure ulcer unresponsive to topical Neosporin, systemic Abx and home health wound care. The ulcer decreased from its original measurement of 2 cm x 1.4 cm x 1.1 cm. Patient managed with Silvaklenz and Silvion and adequate nutrition. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
1 year old - Bilateral Gluteal Ulcer - Clinical Case
1 Year on Other Therapy. Physician Initiated use of SilvaKlenz and Silvion on 10-20-10
25 Days using SilvaKlenz and Silvion
43 Days using SilvaKlenz and Silvion
31 year old, Bedridden male with Morbid Obesity, Chronic Diabetes and MS Bilateral Gluteal Ulcers Unresponsive to Other Therapy since 11-05-09
Day 14
Day 1
A 41 year old with dehiscence 1 week after abdominal surgery. The incision site was packed with a calcium alginate dressing soaked in Silvion and changed daily.
Dehisced Wound - Clinical Case
Ulcer Unresponsive to Antimicrobial Ointments - Clinical Case
61 year old male, on Coumadin with history of Peripheral Blood Clots and Chronic Leg Ulcers. Ulcer approximately 2 weeks old unresponsive to antimicrobial ointments. Initiated BID cleaning with SilvaKlenz, and wetting ulcer and bandage with Silvion.
Day 30
Day of Presentation
Post Traumatic Flapping Injury - Clinical Case
44 year old, female surgeon with post traumatic flapping injury
Initiated SilvaKlenz and Silvion use 12 hours after injury
Day 2
Day 10
3 Days post ‘spur removal’ surgery. Patient returned with severe pain, swelling and ascending cellulitis. Surgical site infected with Streptococcus sp Staphylococcus aureus
Post Surgical Infection - Clinical Case
Culture Negative at 10 Days
Day 29
Approximately 1 week Post Closure
Day 14
using SilvaKlenz and Silvion
BID cleansing with SilvaKlenz, flushed with Silvion. Wound packed with Silvion moistened 1/4 inch strip
Day 14
Day 2
Day 3
Day 4
Day 5
Day 6
Day 8
Fully Resolved
Chin Pressure Ulcer from 7 hr spinal surgery - Clinical Case
28 year old male with chin pressure ulcer secondary to 7 hr surgery in face frame. Ulcer became increasingly inflamed and painful post surgery. Silvaklenz and Silvion use started 2 days after surgery. Days 2 thru 5 ulcer was cleaned twice a day and Silvion was sprayed on the ulcer 4 times per day. Day 5 ulcer covered with Silvion soaked bandage between cleanings.
Post Mastectomy Wound - Clinical Case
Day of Presentation
Post Debridement and Cleansing
Day 8
Post Care
Indications for SilvaKlenz® and Silvion® include:
1st and 2nd Degree Burns, Stage I-IV Pressure Ulcers, Venous Stasis Ulcers,
Diabetic Ulcers, Post Surgical Wounds, Dermal Lesions, Skin Irritation, Abrasions.
FDA Clearance.
Post Mastectomy Wound - Clinical Case
53-year-old female presented for compromised tissue flaps approximately 3 weeks after bilateral mastectomy. Four drains were placed at the time of surgery and 3 had been removed. At presentation the patient had areas of tissue necrosis/ischemia at the left mastectomy site. Wound was debrided and seroma was drained. Patient was successfully managed with serial debridement, cleansing with Silvaklenz, flushing with Silvion and packing the wound with Silvion soaked gauze. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
58-year-old female presented with a 2 month history of a compromised flap associated with post mastectomy reconstruction within the field of irradiated tissue. Post surgery, the patient underwent 18 weeks of chemotherapy and 33 radiation treatments ending 6 months before presentation. 2 months before presentation, the patient underwent TRAM flap reconstruction which then failed with tissue breakdown, necrosis, and production of large amounts of malodorous drainage. Pseudomonas aeruginosa, Enterococcus faecalis and Staphylococcus aureus were isolated from the wound at presentation. The patient was managed with serial debridement, IV abx, a wound VAC, cleaning the wound with Silvaklenz, flushing with Silvion and packing with Silvion soaked gauze. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Day of Presentation
Day 7
Day 15
Post Care
Molecular Therapeutics, Silvion, SilvaKlenz, Potentiator and Potentiated are registered trademarks.
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75-year-old female with diabetes mellitus presented for a Stage IV pressure ulcer of the buttock that had not healed after 9 months of traditional care. Patient was successfully managed with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Chronic (9 months) Non-Healing Pressure Ulcer, Stage IV - Clinical Case
Non-Healing (1 month) Radiation Therapy Wound - Clinical Case
66-year-old male presented for non-healing wound (approximately 1 month) while undergoing radiation therapy. Patient was successfully managed with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Day of Presentation
Post Care
Day of Presentation
Post Care
Non-Healing (4 months) Surgical Wound - Clinical Case
68-year-old male presented for non healing wound (approximately 4 months) after pancreatic cancer surgery and radiation. Patient was successfully managed with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Non-Healing (2 months) Stage 4 Sacral Ulcer Wound - Clinical Case
80-year-old male presented with non-healing (approximately 2 month) stage 4 sacral ulcer with underlying osteomyelitis following hospitalization for surgery. Silvaklenz and Silvion were used for wound management prior to wound closure with a graph. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Non-Healing (2 months) Radiation Therapy Wound - Clinical Case
84-year-old male presented for non healing wound (approximately 2 months) following cancer surgery and radiation therapy. Patient was successfully managed with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Non-Healing (1 month) Pressure Ulcer - Clinical Case
84-year-old male presented for a non healing (approximately 1 month) pressure ulcer of the heel. following cancer surgery and radiation therapy. Patient was successfully managed with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Non-Healing (3 months) Post Surgery Wound - Clinical Case
57-year-old female presented with non-healing (approximately 3 months) wound following tissue flap reconstruction and radiation therapy. Patient was successfully managed with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Non-Healing (3 months) Radiation Therapy Wound - Clinical Case
57-year-old female presented with non-healing (approximately 3 months) post radiation necrosis. Patient was successfully managed with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Non-Healing (7 months) Post Surgical Wound - Clinical Case
46-year-old male presented for a non-healing (approximately 7 months) post-surgical wound. The wound remained open and infected (Bacillus sp. and S. aureus) despite systemic antibiotics, removal of sutures and excision of abscess. Patient was successfully managed with HBOT, Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Non-Healing Grade 3 Ulcer - Clinical Case
66-year-old male with a multi-year history of a recurring diabetic ulcer on the heel. The non-healing Grade 3 ulcer had been present for 2 weeks prior to presentation. Patient was successfully managed with Silvaklenz, Silvion, HBOT and off-loading. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
Non-Healing (3 months) Post Surgical Wound - Clinical Case
71-year-old female presented for a non-healing (approximately 3 months) post-surgical wound of the right knee with a draining sinus track. Patient was successfully managed with Silvaklenz and Silvion. Case courtesy of Dr. Belinda Marcus, M.D., FACEP, CWS - she is currently in practice as the Medical Director for North Fulton Hospital’s Hyperbaric and Wound Care Center.
43-year-old female presented with a herpes-related dermatitis (Shingles) that did not respond to 2 weeks of traditional supportive therapy (Zovirax, Gentamicin and Fambiz). Patient started twice a day use of Silvaklenz and Silvion and the lesions resolved in 5 days.
Day of Presentation
Day 2
Day 3
Day 5
Herpes Related Dermatitis (Shingles) - Clinical Case
39 year old female with a 3 decade history of recurrent HSV lip lesions. Patient reported 3 to 5 cases per year with a typical duration of 10 days when using topical over-the-counter cold-sore medications. Lesions typically were swollen, formed clusters of lesions and would crack and bleed while using topical medications. Patient also reported that the medications were messy and would leave a dried white paste on her mouth for the “entire world to see”. Patient felt tingling in her lip and within an hour wetted a cotton ball with Silvion and held it on the tingling area for 3 to 5 minutes. Patient repeated Silvion application to the affected area of the lip every 3-4 hrs. Patient reported minimal pain, swelling or formation of other clusters of lesions. The lesion did not crack or bleed as was typical using other topical medications. The lesion was completely healed in 6 days (historic time to resolution of lesions using other topical medications was 10 days).
HSV Lip Lesion (Cold Sore) - Clinical Case
24 Hours
Day 3
Day 6
*Representative lesion described as typical by the patient
*Courtesy of herpessimplex1.co
Poison Oak Lesions - Clinical Case
48 Hours
48 Hours
A 41 year old male patient with a 3 day history of a hypersensitivity reaction to poison oak. Patient had used steroid cream with little improvement. Patient reported severe itching, oozing and painful lesions. The wounds were cleaned with Silvaklenz and a Silvion moistened bandage was applied. The bandages were moistened with Silvion every 6 hrs. The bandages were changed and wounds were cleaned with Silvaklenz every 12 hrs. Patient reported a 80% reduction in itching and pain and a 80% reduction in redness within 12 hrs of using Silvaklenz and Silvion and a complete cessation of itching and pain within 48hrs of using Silvaklenz and Silvion.
48 Hours
Day of Presentation
Day of Presentation
Day of Presentation
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Post-Surgical Total Hip Removal and Replacement - Clinical Case
A 65 year old female with Lupus (controlled with chemotherapy) renal failure managed with dialysis at Mayo Clinic, Jacksonville, required the removal and replacement of a Stryker Total Hip Implant.
Day before and morning of surgery the surgical area was wetted with SilvaKlenz (left in place for 5 minutes) gently scrubbed with sterile gauze and rinsed with sterile water. The surgical area was then moistened with Silvion and lightly wrapped with sterile gauze. The surgical site was prepared according to hospital procedures at the time of surgery. After surgery, the incision was sprayed with Silvion. The day after surgery, and BID each day until the incision was healed, the incision site was cleaned with SilvaKlenz, rinsed, then moistened with Silvion. The contact bandage was lightly moistened with Silvion.